A REVOLUTION IN weight loss is apparently underway. Last fall, the US Food and Drug Administration fast-tracked review of the diabetes drug tirzepatide-sold under the brand name Mounjarofor weight loss, after a clinical trial showed that people with a body mass index (BMI) labeled "overweight" or "obese" lost as much as 22.5 percent of their body weight on the highest dose. Upon approval, the weekly injectable will be the latest drug in a booming biomedical sector that aims to combat, if not cure, the problem of "excess" weight.
For pharmaceutical companies, the race to market is, as usual, financially motivated. Weight-loss drugs are rarely covered by insurance, and companies are finding plenty of patients ready to pay more than $1,000 a month for tirzepatide and its cousin semaglutide (brand names: Ozempic and Wegovy). Commentators have hailed these drugs as a "medical breakthrough" and a "silver bullet" for obesity; people from Hollywood to the Hamptons want a prescription. Now, doctors-desperate to treat what is widely seen as an "obesity epidemic" are showing interest.
But victorious narratives around drugs like Mounjaro pose a direct challenge to the fat activism movement. For decades, this movement has pushed for social and economic opportunity for people of all sizes using a variety of rhetorical modes-civil rights, fat pride and liberation, and biomedical evidence itself. Many people now know that "lifestyle changes" like calorie restriction and exercise fail to produce sustained weight loss for 97 percent of people and that many dieters end up gaining back more weight than they lost. But what happens to the strength of these arguments when a weight-loss drug seems to work?
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Denne historien er fra May 2023-utgaven av WIRED.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
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Spin Cycle - To study tornadoes, it helps to wear a skirt (and rocket launchers).
To study tornadoes, it helps to wear a skirt (and rocket launchers). When the Dominator is about to intercept a tornado, Timmer uses a two-prong system to anchor the vehicle. Air compressors lower the car so its thick rubber skirt nearly touches the ground, and spikes wedge 6 inches into the earth to firmly prevent the vehicle from liftoff. Timmer and ONeal have seen roughly 65 tornadoes in the past six months. It was a historic amount, ONeal says. A lot of meteorological setups are busts, but every day we drove out this year, we felt like we would see a tornado.
Fantastic Plastic - a plastic bag might be the most overengineered object in history.
Stretchy seaweed. Reverse vending machines. QR-coded take-out boxes. To cure our addiction to disposable crap, we'll all need to get a little loony.
Piece of Mind - This diagram maps 1 cubic millimeter of the brain-but its unprecedented clarity deepens the mysteries of cognition.
This diagram maps 1 cubic millimeter of the brain-but its unprecedented clarity deepens the mysteries of cognition. Although this image wouldn't look out of place on a gallery wall alongside other splashy works of abstract art, it represents something very real: a 1-cubic-millimeter chunk of a woman's brain, removed during a procedure to treat her for epilepsy. Researchers at Harvard University stained the sample with heavy metals, embedded it in resin, cut it into slices approximately 34 nanometers thick
I Am Laura Kipnis-Bot, and I Will Make Reading Sexy and Tragic Again
WHEN A FLATTERING EMAIL ARRIVED inviting me to participate in an AI venture called Rebind that I'd later come to think will radically transform the entire way booklovers read books, I felt pretty sure it was a scam.
DAMAGE CONTROL
According to Léna Lazare, the 26-year-old face of the radical climate movement, they're also acts of joy.
AN IMPERFECT STORM
CAN THE U.A.E. REALLY MAKE RAIN ON DEMAND OR IS IT SELLING VAPORWARE?
THE HOLE IN THE MAP OF THE WORLD
ON THE SURFACE, THERE'S NOTHING UNUSUAL ABOUT IT. JUST A SPOT OF OCEAN. BUT BENEATH THE WAVES LURKS SOMETHING INCREDIBLE: A MASSIVE WATERFALL. AND IN ITS MYSTERIOUS DEPTHS, THE FATE OF THE WORLD CHURNS.
COOLER HEADS
The deadliest environmental threat to city dwellers worldwide isn't earthquakes, tornadoes, flooding, or fire. It's heat.
TERMINAL VELOCITY
IT WAS 2 AM at Denver International Airport, and Jared Murphy was only a few hours into a planned 17-hour layover.
THE ETERNAL TRUTH OF MARKDOWN
If the robots take over, we should at least speak their language.
