Knowing they needed to beat the Red Devils' youngsters to leapfrog them into second place in Northern Group F, the Terriers made the breakthrough courtesy of Ben Wiles just before the half hour.
Victor Musa levelled three minutes before the break, but Rhys Healey restored Huddersfield's lead midway through the second half.
Late goals from David Kasumu (90 minutes) and Tom Lees (90+7) put the icing on the cake.
The Terriers went through alongside group winners Doncaster.
In Southern Group C, Miles Leaburn (70) scored Charlton's winner as they made it a perfect haul of nine points with a 1-0 home success against EFL newboys Bromley, who bowed out.
Cambridge also advanced.
Stevenage ensured their passage from Southern Group D alongside section winners Peterborough with a 1-1 draw against Gillingham.
Josh Andrews gave the Gills a 26th-minute lead, but Boro got back on terms via Dan Kemp midway through the second period.
Gillingham won the resulting penalty shoot-out 5-4 to pick up an extra point, but still finished bottom.
In Northern Group C, Tom Watson proved to be Wigan's hero as they earned their ticket to the knockout stages with a penalty shoot-out success against Nottingham Forest U21s.
The sides drew 0-0 to both finish on four points and it meant that whoever won the shoot-out would finish runners-up and secure their passage to the last 32.
An inspired Watson saved all three of Forest's spot-kick as the Latics ran out 3-0 victors.
In the same group, winners Morecambe lost 2-1 at home against Carlisle, who still finished bottom.
Hallam Hope gave the Shrimps a 16th-minute lead, but Carlisle hit back courtesy of Freddie O'Donoghue (75) and Ben Williams (78) to sign off on a high note.
In Northern Group G, Chesterfield guaranteed they would finish top with a 3-2 home success against Grimsby.
Denne historien er fra November 17, 2024-utgaven av The Football League Paper.
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Denne historien er fra November 17, 2024-utgaven av The Football League Paper.
Start din 7-dagers gratis prøveperiode på Magzter GOLD for å få tilgang til tusenvis av utvalgte premiumhistorier og 9000+ magasiner og aviser.
Allerede abonnent? Logg på
CLASSY CURTIS GETS HIS REWARD
DERBY County have tied influential centre-back Curtis Nelson down to a new contract that will keep him at Pride Park until 2026.
STATS ALL RIGHT FOR STUDIOUS MK BOSS SCOTT
MK Dons boss Scott Lindsey has highlighted the importance of statistics following his side's recent good form.
SMITH'S FRATTON STUNNER IS TOPS!
MICHAEL Smith's stunning strike for Sheffield Wednesday against Portsmouth has won him the Sky Bet Championship Goal of the Month award for October - but he admitted it could have gone 'over the stand'!
RED DRAGONS SUFER TRIPLE INJURY SETBACK
WREXHAM'S pursuit of a historic promotion from League One has been hit by a triple injury blow.
SMART GUY LAUNCHES AI PLAN TO AID CLUBS
FORMER Rotherham, Hull and Sheffield Wednesday defender Guy Branston has launched a new AI venture that he says will revolutionise the way clubs engage with their fans.
STRIKER BISHOP JUST SO GLAD TO BE BACK
COLBY Bishop has expressed his delight at making an emotional goalscoring return for Portsmouth following open heart surgery this summer.
HUNGRY JAMIE'S IN GOAL GROOVE
Prize winner is followed by Cup heroics
TASTY TERRIERS TAKE A BITE OUT OF UNITED'S YOUNG GUNS
HUDDERSFIELD Town booked their place in the last 32 of the Bristol Street Motors Trophy in style with a thumping 4-1 home win against Manchester United U21s.
KENNY RECEIVES PRAISE OF BOSS BONNER
GILLINGHAM manager Mark Bonner says he will miss leaning on the experience of \"brilliant\" mentor Kenny Jackett.
WEAVER HAPPY TO GIVE ACE ENO HIS SHOT
HARROGATE Town boss Simon Weaver is hoping new striker Eno Nto can solve the Sulphurites' woes in front of goal.
