What the scientists are saying...
A drug to “silence” cholesterol
A new “gene-silencing” drug has been found to reduce cholesterol levels by more than 50% in a clinical trial. Based on a technique known as RNA interference, the drug effectively “switches off” the gene responsible for elevating cholesterol levels. Delivered as an injection, the treatment, inclisiran, could be given twice yearly, with or without statins, depending on the patient’s need, to reduce their risk of heart attack or stroke. For the phase 2 trial, at Imperial College London, researchers gave 497 patients with high cholesterol either inclisiran, at varying doses, or a placebo. Most of the patients were already taking statins. A month after receiving a single treatment of inclisiran, patients’ levels of the harmful low-density lipoprotein (LDL) cholesterol were down by up to 51%. After six months, they were down by up to 42%. By contrast, patients in the control group were showing slightly elevated cholesterol levels. The results were even better for those who had two doses over three months: their LDL levels fell by as much as 53% after six months. Along with its effectiveness, the minimal dosing required sets the treatment apart: rather than having to take a pill daily, patients could visit their doctor twice a year for an injection. However, much more research is needed before it can come on the market.
Noses adapt to their climate
This story is from the April 01, 2017 edition of The Week UK.
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This story is from the April 01, 2017 edition of The Week UK.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
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His Only Crime Was Coming Home
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Donald Trump ran, and won, on a promise to “drain the swamp” of Washington corruption, said Eugene Robinson in The Washington Post. But so far, he seems intent on deepening it. The president-elect owns or has stakes in around 500 companies, at least 111 of which do business overseas. This creates a massive and unprecedented conflict of interest. One of Trump’s biggest lenders, for example, is Germany’s Deutsche Bank, currently negotiating a multibillion-dollar settlement with the Justice Department over abuses that contributed to the 2008 market crash.
What the scientists are saying...
What the scientists are saying...
Cricket: Kohli hammers England
The end was “swift” and brutal, said Vic Marks in The Guardian. On the final morning of the fourth Test, in Mumbai, India needed less than half an hour to take England’s last four wickets. They thrashed the visitors by an innings and 36 runs to seal a 3-0 series victory, with the fifth Test still to be played.
Keeping The Press Under Control
Press freedom is under threat – at least according to recent newspaper reports. What are they so worried about?
The Society Photographer Who Married A Princess
The Earl of Snowdon 1930-2017.
Exhibition Of The Week War In The Sunshine, The British In Italy 1917-18
For most of us, the story of the First World War is defined by the “mud, gas and trenches” of the Western Front, said Waldemar Januszczak in The Sunday Times.
Rock ‘n' Roll Superstar Who Caught the Teen Spirit
Chuck Berry didn’t invent rock ’n’ roll – no one person could claim credit for that.
The Ruthless Ira Commander Who Helped Broker Peace
On 27 August 1979, the Provisional IRA murdered Lord Mountbatten while he was on a family holiday in Sligo, said Henry McDonald in The Guardian.
