Linezolid directly affects the ability of the mitochondria to produce energy
Express Pharma|October 16, 2016

Dr Salil Mehta, Volunteer and Consultant Ophthalmologist with MSF, recently published a paper on optic neuropathy in DR-TB patients in Mumbai. He discusses key takeaways of his research with Sachin Jagdale.

Sachin Jagdale
Linezolid directly affects the ability of the mitochondria to produce energy

Any specific reason behind selecting patients from Mumbai for Linezolid associated optic neuropathy in DR-TB patient study?

There is a combination of reasons. Firstly, MSF has an excellent and a well established TB/HIV clinic in Mumbai. Hence, the expertise is available. Secondly, and more importantly, Mumbai is a global hot spot for tuberculosis (TB). A perfect storm of several factors including extreme population densities, incorrect treatment and poor compliance are leading to high incidence of primary drug sensitive TB and subsequent drug resistance. Worryingly, an increasing number of patients are presenting with primary drug resistant tuberculosis. This makes Mumbai an ideal city to undertake such a study.

Can you take us through this entire study. (How and why was it started? Have you managed to achieve your targets?)

Ever since the use of linezolid became wide spread, available literature suggested potential ocular toxicity. Accordingly, the staff and doctors of MSF conducted primary screening and evaluation for all these patients. Suspect cases were then referred for further evaluation. These patients were fully evaluated, treated and followed up till resolution. It's an ongoing process and hopefully in a few years we will have more data for more research.

This story is from the October 16, 2016 edition of Express Pharma.

Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.

This story is from the October 16, 2016 edition of Express Pharma.

Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.

MORE STORIES FROM EXPRESS PHARMAView All
Powerful Process Control with IND500x Weighing Indicators
Express Pharma

Powerful Process Control with IND500x Weighing Indicators

Ensuring consistent quality in hazardous environments, particularly in Ex-Areas (Zone 1/21, Division 1), is a critical aspect of industrial operations. The IND500x weighing indicators from METTLER TOLEDO provide a robust solution for these challenging settings, offering optimized safety and productivity.

time-read
1 min  |
November 2024
Ensuring clean room integrity with prime clean reset high-speed doors
Express Pharma

Ensuring clean room integrity with prime clean reset high-speed doors

Prime Clean Reset high-speed doors ensure airtight seals, minimising air permeability and contamination in clean rooms. Designed for sensitive environments, they enhance operational efficiency and meet rigorous regulatory standards, making them ideal for pharmaceutical and biotech industries

time-read
3 mins  |
November 2024
Complete environmental monitoring solution - testo Saveris Pharma
Express Pharma

Complete environmental monitoring solution - testo Saveris Pharma

There are several critical applications in the industry like research and development that demand for continuous & reliable monitoring of important environmental parameters.

time-read
3 mins  |
November 2024
Adaptive Manufacturing:-The new flexibility in medical device assembly
Express Pharma

Adaptive Manufacturing:-The new flexibility in medical device assembly

Unlike traditional, rigid production lines, B&R's adaptive machines seamlessly adjust to the requirements of each device, dynamically adapting to each unique process

time-read
3 mins  |
November 2024
Reshaping pharma safety with active packaging innovations
Express Pharma

Reshaping pharma safety with active packaging innovations

CILICANT is revolutionising active packaging with solutions tailored for the most sensitive formulations. Meet the innovators driving stability, safety, and impurity control in pharma packaging at CPhI India

time-read
1 min  |
November 2024
UNLOCKING GROWTH FRONTIERS
Express Pharma

UNLOCKING GROWTH FRONTIERS

Vadodara Pharma Summit 2024 brought together industry leaders and experts to highlight the city's pivotal role in India's pharma landscape and explore collaborative strategies to strengthen India's pharma innovation ecosystem

time-read
9 mins  |
November 2024
Optimising cloud provisioning for pharmaceutical compliance and operational excellence
Express Pharma

Optimising cloud provisioning for pharmaceutical compliance and operational excellence

Suresh Perikala, Senior Engineering Lead - DevOps and Cloud Engineering Practice, Altimetrik

time-read
3 mins  |
November 2024
Accelerating pharma's sustainability efforts
Express Pharma

Accelerating pharma's sustainability efforts

Avinaw Prasad, Director, Climate Change & Sustainability, Deloitte India explains why integrating sustainability into the core pharma business strategy is essential for long-term success, analyses key focus areas and policy pushes which can incentivise companies to further evolve on the sustainability path

time-read
5 mins  |
November 2024
Drug Repurposing: Unlocking access to rare solutions
Express Pharma

Drug Repurposing: Unlocking access to rare solutions

Drug repurposing, a quick, cost-effective path to deliver existing treatments to patients, can serve to expedite and expand healthcare access for patients with rare diseases

time-read
8 mins  |
November 2024
Optimising spend, maximising growth
Express Pharma

Optimising spend, maximising growth

Express Pharma, in partnership with IPA and CHEMEXCIL, powered by SAP, recently organised a thought leadership conclave on 'Reimagining spend management and supply chain' where cross functional experts explored strategies to drive value through supply chain transformation

time-read
7 mins  |
November 2024