The research, published in the Journal of the American Medical Association, analysed variation of the genetic makeup of four young male patients with severe COVID-19 from two families, who did not have any preexisting medical conditions that made them predisposed to the deadly disease.<div style="page-break-before:always; page-break-after:always">According to the scientists from Radboud University Medical Center in the Netherlands, the patients had variants of the gene TLR7, along with defects in the production of immune system molecules type I and II interferons. They said the patients who were previously well before developing respiratory insufficiency due to severe COVID-19, required mechanical ventilation in the ICU.A rapid clinical sequencing of all the genes performed in the study, and segregation in available family members, found that the variants of the TLR7 gene in the patients had a loss-of-function. In this case series of four young male patients with severe COVID-19, rare putative loss-of-function variants of X-chromosomal TLR7 were identified that were associated with impaired type I and II IFN responses, the scientists wrote in the study.

Genetic Mutation That Makes Some People Vulnerable Found

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