The findings by the Health Research Board (HRB) were presented at the Citizens' Assembly on Drug Use yesterday.
According to the HRB, 409 deaths in 2020 were poisonings and eight in 10 of those involved more than one drug; seven in 10 deaths involved opioids.
Methadone was implicated in three in 10 poisonings and heroin, two in 10.
Three in 10 involved cocaine while almost six in 10 deaths involved other prescription drugs, most commonly antidepressants and antiepileptics.
The Assembly's chairman, Paul Reid, said the shocking number of drug-related deaths should act as a wake-up call for the country.
He added such statistics are a strong reminder to Assembly members of the urgent need to produce meaningful and effective recommendations to reduce the devastating harm caused by drug use.
HRB researcher Dr Suzi Lyons said the findings showed that mixing drugs was a major factor in poisoning deaths.
Dr Lyons added: "We also see the growing prevalence of cocaine, implicated in 130 deaths in 2020 compared to 24 in 2011.

Wake-up call as over 400 poisoned in space of year

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