Edwards was ruled out of the 1-0 defeat at Burnley on Tuesday night after picking up a minor knock, while 18-year-old Issaka has not played since he jarred a knee while on international duty with Wales under-19s last month. Adam Forshaw continues to be sidelined by a hamstring issue and another midfielder, Caleb Roberts, is close to completing his concussion protocol after suffering a head injury.
Goalkeeper Conor Hazard (ankle ligaments) and striker Muhamed Tijani (hamstring) are both longterm injury absentees, but head coach Wayne Rooney hopes to be able to include Andre Gray, the 33-year-old Jamaica international striker, in his matchday squad against Blackburn as long as the new signing gets international clearance in time after last playing in Saudi Arabia for Al-Riyadh.
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