Trippy Treatments
Newsweek|October 01, 2021
Psilocybin, the active ingredient in “magic mushrooms,” is undergoing clinical trials. It could be the biggest advance in treating depression since Prozac.
By Adam Piore
Trippy Treatments

For most of his adult life, Aaron presley, age 34, felt like a husk of a person, a piece of “garbage.” He was trapped in a reality that was so excruciatingly tedious that he had trouble getting out of bed in the morning. Then, all at once, the soul-crushing, depressive fog started to lift, and the most meaningful experience of his life began.

The turning point for Presley came as he lay on a psychiatrist’s couch at Johns Hopkins University, wearing an eyeshade and listening through a pair of Bose headphones to a Russian choir singing hymns. He had consumed a large dose of psilocybin, the active ingredient in what’s more commonly known as magic mushrooms, and entered a state that could best be described as lucid dreaming. Visions of family and childhood triggered overwhelming and long-lost feelings of love, he says, “like heaven on earth.”

Presley was one of 24 volunteers taking part in a small study aimed at evaluating the effectiveness of a combination of psychotherapy and this powerful mind-altering drug to treat depression—an approach that, should it win approval, could be the biggest advance in mental health since Prozac in the 1990s.

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