Researchers in the US said almost all of the people who carry two copies of the APOE4 gene variant, known as APOE4 homozygotes, are likely to develop signs of the neurological condition.
They said this gene is already associated with a higher risk of developing Alzheimer’s.
But scientists now believe 95 per cent people who are over 65 and carry two copies of APOE4 show early signs of the disease, making it a distinct genetic form of Alzheimer’s.
These people also develop the condition earlier than those with other variants of the APOE gene, they added.
The findings, published in the journal Nature Medicine, are based on clinical data from more than 10,000 people, as well as pathological data from more than 3,000 brain donors.
Dr Juan Fortea, director of the research area on neurological diseases, neuroscience, and mental health at the Sant Pau Research Institute in Barceclona, Spain, said: “These data represent a reconceptualisation of the disease or what it means to be homozygous for the APOE4 gene.
Bu hikaye The Independent dergisinin May 07, 2024 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber ? Giriş Yap
Bu hikaye The Independent dergisinin May 07, 2024 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber? Giriş Yap
Champion Humphries eases through to last 16
World number one Luke Humphries continued his bid for back-to-back World Championship titles after easing through to the last 16 last night.
Contract conundrum won't distract Reds' title charge
New year, new context. Liverpool will enter 2025 top of the Premier League, a year of seismic change that could have sent them spiralling downwards instead sees them ending on a high.
Gunners edge victory against battling Ipswich
Arsenal moved into second place in the Premier League table with a 1-0 win over Ipswich at the Emirates.
'They are erasing us. They are erasing our history'
Indie filmmaker Arfat Sheikh was increasingly frustrated by mainstream cinema’s depiction of Kashmir and its people so he decided to make his own. Maroosha Muzaffar reports
South Korea’s MPs vote to impeach acting president
South Korea's parliament impeached acting president Han Duck Soo yesterday, just two weeks after similarly punishing president Yoon Suk Yeol for briefly declaring martial law earlier this month.
Russian air defence 'likely' behind crash that killed 38
The deadly Christmas Day crash of an Azerbaijan Airlines plane in Kazakhstan was likely caused by a Russian air defence system, military and aviation experts have said.
'We cannot wait for peace before beginning to rebuild'
As fears mount for Ukraine's future in light of the re-election of Trump, Tom Watling speaks to politicians, military experts and aid workers to discover what the coming year could hold
Quad bike crash leaves girl with life-changing injuries
A child has been left with life-changing injuries after the quad bike she was riding on crashed into a telegraph pole outside a high-street pub on Boxing Day.
Christmas travel chaos as fog causes mass flight delays
Airline passengers hoping to jet off ahead of the New Year were hit by severe delays, as thick fog caused chaos at the UK's busiest airports.
Snow could sweep through UK as new year approaches
Britons are bracing for snowfall and a sharp drop in temperatures, which are set to fall to -2C on New Year's Eve in some places.
