Some of the medical entities include but not limited to vaccines, nucleic acids, small molecules, convalescent serum, intravenous immunoglobulin (IgG) and monoclonal antibodies (mAbs) or their coformulation. Among them, vaccination is a preferred approach for prevention and treatment of COVID-19 induced disease, however the vaccine evolution is plagued by time constrains and manufacturing hurdles. The massive economic and social impact of corona virus has propelled the scientific and government organizations to accelerated the vaccine development. Figure 1 demonstrates multiple platforms of vaccine models targeted against the COVID-19 pandemic causing virus, amid that race two types of vaccine technologies appeared as front runners 1) Non-replicating viral vector (Gene therapy) and 2) Nucleic acid (mRNA) based, where the former delivers the target antigen to the antigen-presenting cells via adenoviral vector while the later via mRNA packed lipid nano-particles.
The vaccine candidates advanced through both platforms express neutralizing antibodies that target the spike protein of the coronavirus and inhibits its binding to the human ACE2 protein and prevent infection. ChAd Ox1 viral vector developed by University of Oxford in collaboration with AstraZeneca is the prime example of non-replicating gene therapy-based vaccine, while the Moderna's mRNA SARS COV-2 vaccine candidate (mRNA-1273) is an exemplary for nucleic acid-based vaccine.
Bu hikaye Scientific India dergisinin September - October 2020 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber ? Giriş Yap
Bu hikaye Scientific India dergisinin September - October 2020 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber? Giriş Yap
Building world's 1st pyramid
In a preprint study published this summer, researchers proposed that ancient Egyptians built the world's first pyramid the 4,700-year-old Step Pyramid of Djoser, which sits on Egypt's Saqqara plateau using a \"modern hydraulic system\" powered by a long-gone branch of the Nile River.
Climate change arms the world, ovarian cancer pulls the trigger.It's time we disarm them both
Climate change, driven by human activities, leads to environmental changes such as rising temperatures, altered weather patterns, and increased pollution.
Climate Change Added 18 mph to Hurricane Wind Speeds over Past 5 Years
High ocean temperatures caused by global warming boosted maximum intensities for most storms between 2019 and 2023, as well as for every 2024 hurricane.
How Indian Vulture Decline Led to 500,000 Deaths in 5 Years
Once a common sight across India, vultures were abundant scavengers, often seen circling landfills in search of carcasses.
Understanding Monkeypox: Insights and Implications
Monkeypox, a viral zoonotic disease, has gained significant attention in recent years due to its re-emergence and sporadic outbreaks globally.
AI predicts that most of the world will see temperatures rise to 3°C much faster than previously expected
Three leading climate scientists have combined insights from 10 global climate models and, with the help of artificial intelligence (AI), conclude that regional warming thresholds are likely to be reached faster than previously estimated.
Infrared Radiation: A New Player In Mosquito Host-Seeking
The sound of mosquitoes is all around us when the sun sets and the air gets warm and sweltering.
Fish Oil May Benefit to Cure Alzheimer's, disorder: new findings
The benefits of fish and fish oil consumption are well-known in medical science as fish is considered a precious food resource that provides sufficient nutrition to humans.
A new class of antivirals could help prevent future pandemics
The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic an effective antiviral that has since successfully treated millions.
Turning carbon emissions into methane fuel
Chemists have developed a novel way to capture and convert carbon dioxide into methane, suggesting that future gas emissions could be converted into an alternative fuel using electricity from renewable sources. Carbon dioxide (CO2) is a greenhouse gas that accounts for a large part of Earth's warming climate, and is produced by power plants, factories and various forms of transportation.
