In early 2021, Dr. Michael Ombrello, an investigator at the National Institutes of Health, received a message from doctors at Yale about a patient with a novel genetic mutation—the first of its kind ever seen. A specialist in rare inflammatory and immune disorders, Ombrello was concerned by what first-round genetic tests showed: a disabling mutation in a gene, known as PLCG2, that’s crucial for proper immune functioning. It was hard to discern how the patient, a forty-eightyear-old woman, had survived for so long without serious infections. Even more puzzling was the sudden onset of severe joint pain and swelling she was experiencing after years of excellent health. He decided to bring her to the N.I.H. campus, in Bethesda, Maryland, to study her case first hand.
That’s how I ended up as a patient in his clinic on a sweet, warming day in April, 2021, just as the cherry blossoms in the Washington area were in full bloom. As a historian and a biographer, I am used to conducting research, examining other people’s lives in search of patterns and insights. That spring, I became the research subject. At the N.I.H., Ombrello’s team took twenty-one vials of my blood and stored a few of them in liquid nitrogen for future use. Scientists outside the N.I.H. began to study me, too. In the past few years, my case has been examined by specialists at Yale, Harvard, Columbia, and the University of Pennsylvania—by immunologists, rheumatologists, dermatologists, pulmonologists, and experts in infectious disease. It has been debated at hospital grand rounds and global medical conferences, and in high-powered conference calls. There are PowerPoint decks about it.
Bu hikaye The New Yorker dergisinin January 30, 2023 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber ? Giriş Yap
Bu hikaye The New Yorker dergisinin January 30, 2023 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber? Giriş Yap
BADDIE ISSUES
\"Wicked\" and \"Gladiator II.\"
LET'S MAKE A DEAL
\"Death Becomes Her\" and \"Burnout Paradise.\"
ANTI HEROES
\"The Franchise,\" on HBO.
FELLOW-TRAVELLERS
The surprisingly sunny origins of the Frankfurt School.
NOW YOU SEE ME
John Singer Sargent's strange, slippery portraits of an art dealer's family.
PARIS FRIEND - SHUANG XUETAO
Xiaoguo had a terror of thirst, so he kept a glass of water on the table beside his hospital bed. As soon as it was empty, he asked me to refill it. I wanted to warn him that this was unhealthy - guzzling water all night long puts pressure on the kidneys, and pissing that much couldn't be good for his injury. He was tall, though, so I decided his insides could probably cope.
WILD SIDE
Is Lake Tahoe's bear boom getting out of hand?
GETTING A GRIP
Robots learn to use their hands.
WITHHOLDING SEX FROM MY WIFE
In the wake of [the] election, progressive women, who are outraged over Donald Trump's victory at the ballot box, have taken to social media with public, vengeful vows of chastity. - The Free Press.
DEADLINE EXTENSION
Old age, reborn.