A REVOLUTION IN weight loss is apparently underway. Last fall, the US Food and Drug Administration fast-tracked review of the diabetes drug tirzepatide-sold under the brand name Mounjarofor weight loss, after a clinical trial showed that people with a body mass index (BMI) labeled "overweight" or "obese" lost as much as 22.5 percent of their body weight on the highest dose. Upon approval, the weekly injectable will be the latest drug in a booming biomedical sector that aims to combat, if not cure, the problem of "excess" weight.
For pharmaceutical companies, the race to market is, as usual, financially motivated. Weight-loss drugs are rarely covered by insurance, and companies are finding plenty of patients ready to pay more than $1,000 a month for tirzepatide and its cousin semaglutide (brand names: Ozempic and Wegovy). Commentators have hailed these drugs as a "medical breakthrough" and a "silver bullet" for obesity; people from Hollywood to the Hamptons want a prescription. Now, doctors-desperate to treat what is widely seen as an "obesity epidemic" are showing interest.
But victorious narratives around drugs like Mounjaro pose a direct challenge to the fat activism movement. For decades, this movement has pushed for social and economic opportunity for people of all sizes using a variety of rhetorical modes-civil rights, fat pride and liberation, and biomedical evidence itself. Many people now know that "lifestyle changes" like calorie restriction and exercise fail to produce sustained weight loss for 97 percent of people and that many dieters end up gaining back more weight than they lost. But what happens to the strength of these arguments when a weight-loss drug seems to work?
Bu hikaye WIRED dergisinin May 2023 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber ? Giriş Yap
Bu hikaye WIRED dergisinin May 2023 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber? Giriş Yap
A Full-Term Gig - Hiring someone to carry your baby to term is a booming business.
Hiring someone to carry your baby to term is a booming business. The market for surrogacy is expected to expand to $129 billion by 2032, fueled by older parents, rising infertility, and more same-sex families. Silicon Valley contributes to the growth too: Tech companies like Google, Meta, and Snap pitch in up to $80,000 toward the six-figure cost of the process.
Inside the Uncanny World of TikTok Home Remodeling - Turn a tree into a luxury apartment. Retrofit a bedroom for a million children. The videos are bizarre-and going very viral. Who's behind them?
If you've been on TikTok at any point in the past six months, chances are you've stumbled across them, as I first did during a fairly routine doomscroll one night this summer. For me it started with two videos somewhat incongruously tagged #homeremodeling and #housedesign. One of them featured a CGI man summoning a baby phoenix outside of a tree that he planned to turn into an apartment. Then a robotic AI voice started to narrate how the CGI man, identified as Little John, was going to build it. Over the next 90 seconds, Little John transformed the tree into a maniacally space-efficient luxury unit in an AI-generated ballet of flying galvanized square steel, ecofriendly wood veneer, and expansion screws.
The Hole in the Map of the World - On the surface, there's nothing unusual about it. just a spot of ocean. but beneath the waves lurks something incredible: a massive waterfall. and in its mysterious depths, the fate of the world churns.
Tip of Iceland, you'll find what's often called a marginal body of water. This part of the Atlantic, the Irminger Sea, is one of the stormiest places in the northern hemisphere. On Google Maps it gets three stars: very windy, says one review. It's also where something rather strange is happening. As the rest of the planet has warmed since the 20th century-less in the tropics, more near the poles-temperatures in this patch of ocean have hardly budged. In some years they've even cooled. If you get a thrill from spooky maps, check out one that compares the average temperatures in the late 19th century with those of the 2010s. All of the planet is quilted in pink and red, the familiar colors of climate change. But in the North Atlantic, there's one freak splotch of blue. If global warming were a blanket, the Irminger Sea and its neighboring waters are where the moths ate through. Scientists call it the warming hole.
The Eternal Truth of Markdown -An exegesis of the most ubiquitous piece of code on the web.
Markdown is not just a piece of software. It's also a markup language it's used to format plaintext, which then appears the way you want it to on, say, the internet. Markdown the markup language was designed to be as easy-to-read and easy-to-write as is feasible, according to creator John Gruber's syntax guide. A Markdown-formatted document should be publishable as-is, as plain text, without looking like it's been marked up with tags or formatting instructions.
Terminal Velocity - Murphy, a competitive runner since high school, was an avid user of the exercise app Strava, and he frequently checked the app while traveling to see where locals liked to run.
It was 2 am at Denver International Airport, and Jared Murphy was only a few hours into a planned 17-hour layover. His options at this quiet hour, in the expansive halls of the concourse, were pretty much nil. There would be no nibbling on ahi tartare at the Crú Food & Wine Bar for at least another seven hours, and the Rocky Mountain Chocolate Factory's signature caramel apples had long since been cached for the night.
What's the future for Western 'super apps'?
Super apps create a single interface to unify a broad ecosystem of services such as messaging, e-commerce, and transport. With consumers making all of their purchases within one walled garden, the user engagement and data benefits for the app owner are obvious and substantial. These apps have become a major part of the Chinese technology landscape, so we asked two leading experts: Could the concept successfully break through in Western markets?
THE TELEVISUAL HIJACKING OF ALFONSO CUARON
Gravity, Children of Men, the best Harry Potter film-and now a seven-part miniseries?
THE MILITARY INDUSTRIAL COMPLEXES TRAE STEPHENS
The venture capitalist and cofounder of the defense-tech startup Anduril has worked with Donald Trump, Peter Thiel, Palmer Luckey, and Elon Musk.
THE ULTRACOOL CASH GRABS OF BOOBI ALTHOFF
Now the Tik Tokker turned podcaster is out to prove her worth-by being herself.
THE MIDLIFE NOT -A-CRISIS OF MARK CUBAN
Though he's soon to be out at Shark Tank, the billionaire has a massive new \"disruption\" in the works. He's certain it'll save lives.
