Titanium dioxide (TiO2) isthe most widely usedwhite pigment in pharmaceutical/nutraceutical coating formulations.
It has high brightness and a very high refractive index. Apart from producing a white colour in liquids, paste or as coatings on solids, TiO2 is also an effective opacifier. High Opacity is a fundamental requirement of most pharma coating systems.
However there has been recent suggestions that titanium dioxide (TiO2) is a potential carcinogen. Hence many pharmaceutical companies are now avoiding use of titanium dioxide in their pharma and nutra products. Alternative opacifiers which are non-toxic, economical and safe for consumption are available. The aim of the study was to develop an optimised Instanute IR ready-mix formulation containing alternative opacifiers to titanium dioxide.
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