MARCUS SMITH has been ruled out of England's Six Nations opener against Italy on Saturday in a hammer blow for Steve Borthwick's side.
And in a potential second setback, scrum-half Alex Mitchell has not trained for the last two days in Spain because of an infected leg wound.
Fly-half Smith injured his calf before limping out of practice on Monday in Girona and scans ruled him out of the Italy clash.
England have asked for a second scan on the 24-year-old to clear up whether he will be available for their next game, a clash with Wales a week on Saturday.
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