Centre Emily Scarratt will lead the side against Italy in the absence of Hunter.
England head coach Simon Middleton said he was “disappointed” to leave out Hunter but explained he wanted her to “recover properly” with “a big year ahead”, referencing the World Cup that takes place in 11 months’ time.
Scrum-half Natasha Hunt has withdrawn from the squad after returning a positive Covid-19 test but flanker Marlie Packer is in the matchday 23 after nine months out.
Gloucester-Hartpury captain Hunt will isolate for ten days before undertaking a seven-day return to play programme. Wasps’ Claudia MacDonald will now start at scrumhalf while Leanne Riley joins the group and takes her place on the bench.
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Unbeaten Lymm put the Tykes on a leash
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Dramatic late win boosts leaders
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England need to be more consistent
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Cuthbert: Wales have to deliver
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Anyanwu heads the list of star attractions
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Goldthorp can challenge Kildunne for No.15 spot
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Four-try David calls the shots for Bears
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Scott-Young keen to follow his father
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When value for money is not part of the deal
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'I want to prove my worth to Bath'
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