Developmental challenges and some solutions for the Front Runner Covid-19 Vaccines
Scientific India|September - October 2020
The emergence of SARS-COVID -19 pandemic has propelled Tthe biotech industry to accelerate the development of several biological modalities.
- Sashi Kasimsetty
Developmental challenges and some solutions for the Front Runner Covid-19 Vaccines

Some of the medical entities include but not limited to vaccines, nucleic acids, small molecules, convalescent serum, intravenous immunoglobulin (IgG) and monoclonal antibodies (mAbs) or their coformulation. Among them, vaccination is a preferred approach for prevention and treatment of COVID-19 induced disease, however the vaccine evolution is plagued by time constrains and manufacturing hurdles. The massive economic and social impact of corona virus has propelled the scientific and government organizations to accelerated the vaccine development. Figure 1 demonstrates multiple platforms of vaccine models targeted against the COVID-19 pandemic causing virus, amid that race two types of vaccine technologies appeared as front runners 1) Non-replicating viral vector (Gene therapy) and 2) Nucleic acid (mRNA) based, where the former delivers the target antigen to the antigen-presenting cells via adenoviral vector while the later via mRNA packed lipid nano-particles.

The vaccine candidates advanced through both platforms express neutralizing antibodies that target the spike protein of the coronavirus and inhibits its binding to the human ACE2 protein and prevent infection. ChAd Ox1 viral vector developed by University of Oxford in collaboration with AstraZeneca is the prime example of non-replicating gene therapy-based vaccine, while the Moderna's mRNA SARS COV-2 vaccine candidate (mRNA-1273) is an exemplary for nucleic acid-based vaccine.

この蚘事は Scientific India の September - October 2020 版に掲茉されおいたす。

7 日間の Magzter GOLD 無料トラむアルを開始しお、䜕千もの厳遞されたプレミアム ストヌリヌ、9,000 以䞊の雑誌や新聞にアクセスしおください。

この蚘事は Scientific India の September - October 2020 版に掲茉されおいたす。

7 日間の Magzter GOLD 無料トラむアルを開始しお、䜕千もの厳遞されたプレミアム ストヌリヌ、9,000 以䞊の雑誌や新聞にアクセスしおください。

SCIENTIFIC INDIAのその他の蚘事すべお衚瀺
An insight into Chandipura virus in India
Scientific India

An insight into Chandipura virus in India

Recently lot of news regarding disease due to Chandipura virus has emerged in various newspapers/magazines. After reading the reports published it seems that thing is still brewing in the natures nest and it could affect mankind.

time-read
3 分  |
September - October 2024
Why elephants never forget?
Scientific India

Why elephants never forget?

An elephant has a very large brain for its size and the 'temporal lobe' region responsible for memory is more developed with a greater number of folds - this results in powerful abilities to 'download' important survival data such as where to find food and water, and who is friend or foe.

time-read
1 min  |
September - October 2024
Use of Algae for Wastewater Treatment Containing Heavy Metals
Scientific India

Use of Algae for Wastewater Treatment Containing Heavy Metals

Wastewater treatment is a critical environmental issue particularly when it comes to the removal of heavy metals.

time-read
3 分  |
September - October 2024
Nano priming Seeds: A Small Innovation Sparkling Big Advances in Germination
Scientific India

Nano priming Seeds: A Small Innovation Sparkling Big Advances in Germination

Nanopriming is an emerging agricultural technique where the seeds are treated with nanoparticles to improve their germination, growth, and overall performance.

time-read
4 分  |
September - October 2024
Nobel Laureates in Physics 2024: Revolutionizing AlThe Physics Foundations Behind Machine Learning
Scientific India

Nobel Laureates in Physics 2024: Revolutionizing AlThe Physics Foundations Behind Machine Learning

This year's two Nobel Laureates in Physics have used tools from physics to develop methods that are the foundation of today's powerful machine learning.

time-read
2 分  |
September - October 2024
Revolutionizing Biology: The 2024 Nobel Prize in Chemistry Celebrates Breakthroughs in Protein Design and Structure Prediction
Scientific India

Revolutionizing Biology: The 2024 Nobel Prize in Chemistry Celebrates Breakthroughs in Protein Design and Structure Prediction

The Nobel Prize in Chemistry 2024 is about proteins, life's ingenious chemical tools.

time-read
2 分  |
September - October 2024
New findings on animal viruses with potential to infect humans
Scientific India

New findings on animal viruses with potential to infect humans

Scientists investigating animal viruses with potential to infect humans have identified a critical protein that could enable spillover of a family of organisms called arteriviruses.

time-read
2 分  |
September - October 2024
Father-Daughter Team Decodes Mars' Alien Signal
Scientific India

Father-Daughter Team Decodes Mars' Alien Signal

There is no definitive answer to whether aliens exist, but there is a lot of work being done to find out:

time-read
2 分  |
September - October 2024
Krishi Vigyan Kendras: Working for Farmer's Welfare
Scientific India

Krishi Vigyan Kendras: Working for Farmer's Welfare

Krishi Vigyan Kendras (Farm Science Centres) are the District level institution serving as an agriculture knowledge resource & capacity development centre which plays indispensable role in front line extension regarding agriculture system in scientific way.

time-read
4 分  |
July-August 2024
Sixth generation Computer: The future computing technology
Scientific India

Sixth generation Computer: The future computing technology

We are in a transition towards a digital world, where everything will be dealt with in digital format.

time-read
4 分  |
July-August 2024