Developmental challenges and some solutions for the Front Runner Covid-19 Vaccines
Scientific India|September - October 2020
The emergence of SARS-COVID -19 pandemic has propelled Tthe biotech industry to accelerate the development of several biological modalities.
Sashi Kasimsetty
Developmental challenges and some solutions for the Front Runner Covid-19 Vaccines

Some of the medical entities include but not limited to vaccines, nucleic acids, small molecules, convalescent serum, intravenous immunoglobulin (IgG) and monoclonal antibodies (mAbs) or their coformulation. Among them, vaccination is a preferred approach for prevention and treatment of COVID-19 induced disease, however the vaccine evolution is plagued by time constrains and manufacturing hurdles. The massive economic and social impact of corona virus has propelled the scientific and government organizations to accelerated the vaccine development. Figure 1 demonstrates multiple platforms of vaccine models targeted against the COVID-19 pandemic causing virus, amid that race two types of vaccine technologies appeared as front runners 1) Non-replicating viral vector (Gene therapy) and 2) Nucleic acid (mRNA) based, where the former delivers the target antigen to the antigen-presenting cells via adenoviral vector while the later via mRNA packed lipid nano-particles.

The vaccine candidates advanced through both platforms express neutralizing antibodies that target the spike protein of the coronavirus and inhibits its binding to the human ACE2 protein and prevent infection. ChAd Ox1 viral vector developed by University of Oxford in collaboration with AstraZeneca is the prime example of non-replicating gene therapy-based vaccine, while the Moderna's mRNA SARS COV-2 vaccine candidate (mRNA-1273) is an exemplary for nucleic acid-based vaccine.

この記事は Scientific India の September - October 2020 版に掲載されています。

7 日間の Magzter GOLD 無料トライアルを開始して、何千もの厳選されたプレミアム ストーリー、9,000 以上の雑誌や新聞にアクセスしてください。

この記事は Scientific India の September - October 2020 版に掲載されています。

7 日間の Magzter GOLD 無料トライアルを開始して、何千もの厳選されたプレミアム ストーリー、9,000 以上の雑誌や新聞にアクセスしてください。

SCIENTIFIC INDIAのその他の記事すべて表示
Krishi Vigyan Kendras: Working for Farmer's Welfare
Scientific India

Krishi Vigyan Kendras: Working for Farmer's Welfare

Krishi Vigyan Kendras (Farm Science Centres) are the District level institution serving as an agriculture knowledge resource & capacity development centre which plays indispensable role in front line extension regarding agriculture system in scientific way.

time-read
4 分  |
July-August 2024
Sixth generation Computer: The future computing technology
Scientific India

Sixth generation Computer: The future computing technology

We are in a transition towards a digital world, where everything will be dealt with in digital format.

time-read
4 分  |
July-August 2024
Massive Underground Water Reservoir Found on Mars
Scientific India

Massive Underground Water Reservoir Found on Mars

Scientists have discovered a reservoir of liquid water on Mars deep in the rocky outer crust of the planet.

time-read
1 min  |
July-August 2024
Tofu: The Budget-Friendly Superfood for Vegetarians
Scientific India

Tofu: The Budget-Friendly Superfood for Vegetarians

Tofu is a plant-based protein-rich food item that can be easily prepared at the household level with limited resources.

time-read
3 分  |
July-August 2024
Exploring the Marvels of Carbon Quantum Dots: A Leap into the Future of Nanotechnology
Scientific India

Exploring the Marvels of Carbon Quantum Dots: A Leap into the Future of Nanotechnology

In the ever-changing world of nanotechnology, carbon quantum dots (CQDs) have emerged as super tiny but incredibly powerful entities that have massive potential in various fields.

time-read
2 分  |
July-August 2024
Sniffing Cancer- Honeybee, a potential cancer detector?
Scientific India

Sniffing Cancer- Honeybee, a potential cancer detector?

Imagine harnessing the super-sense of a honeybee to sniff out lung cancer.

time-read
3 分  |
July-August 2024
From Ancient Roots to Modern Remedies: The Timeless Value of Turkey Berry in Nature's Healing Arsena
Scientific India

From Ancient Roots to Modern Remedies: The Timeless Value of Turkey Berry in Nature's Healing Arsena

The Timeless Value of Turkey Berry in Traditional and Modern Medicine

time-read
7 分  |
July-August 2024
Massive biomolecular shifts occur in our 40s and 60s
Scientific India

Massive biomolecular shifts occur in our 40s and 60s

If it's ever felt like everything in your body is breaking down at once, that might not be your imagination.

time-read
3 分  |
July-August 2024
Pectin: An Esteemed Plant-Derived Molecule in the Food Industry
Scientific India

Pectin: An Esteemed Plant-Derived Molecule in the Food Industry

This article provides a concise overview of the significance of pectin, a plant-derived molecule, in the food industry.

time-read
8 分  |
July-August 2024
Skip the Antibacterial Soap: Use Plain Soap and Water
Scientific India

Skip the Antibacterial Soap: Use Plain Soap and Water

When you buy soaps and body washes, do you reach for products labeled \"antibacterial\" hoping they'll keep your family safer? Do you think those products will lower your risk of getting sick, spreading germs or being infected? According to the U.S.

time-read
2 分  |
July-August 2024