Slade made his first appearance of the season in Exeter's defeat by Harlequins on Sunday having undergone shoulder surgery, completing 55 minutes before being withdrawn.
That run out is deemed enough to give him the nod ahead of the in-form Alex Lozowski, with the Chiefs playmaker an influential figure in the team's aggressive 'blitz' defensive system.
The three-way battle at scrum-half has been won by Ben Spencer, who will make his first start for England having won all six previous caps in a five-year Test career off the bench.
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Ruud reveals Ten Hag 'hurt' by his sacking, and chats with legend Fergie
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