Underresearched and often dismissed, migraines have made their sufferers a resourceful bunch. But a promising new drug might finally offer relief.
To be clear: A migraine is not a headache, and people with migraines don’t like their condition to be called one. It’s not that headaches aren’t a part of a migraine: They are. But a headache is a single symptom of a multifaceted neurological disease— one that includes loss of vision, nausea, and sensitivity to light, sound, and smell. And those are just the common side effects. Some sufferers find themselves yawning compulsively, slurring their speech, and losing sensation on one side of their bodies. Some migraineurs (yes, that is the technically accurate moniker for migraine sufferers) start seeing big things as small—a side effect dubbed “Alice in Wonderland syndrome” by doctors.
Nonetheless, for as long as they have existed, migraines have been trivialized as headaches, or dismissed altogether. Which is clear when you look at the treatments available: Almost every drug used between 1550 B.C. and today has been a repurposed one. Poultices of opium and honey, Botox, antidepressants—drugs whose efficacy was not intended but stumbled upon. Triptan, a class of vessel constrictors created to abort (not prevent) attacks at their onset, was released in 1991 and has been the only class of drug created specifically for migraines—that is, until now. On May 17, a preventative drug called Aimovig, 30 years in the making, gained FDA approval; it’s a monthly shot that modulates patients’ levels of CGRP, a neurotransmitter whose levels rise during migraine attacks. This means that it could be in the hands (or arms— it’s injectable) of migraineurs within the month.
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Denne historien er fra May 28, 2018-utgaven av New York magazine.
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Early and Often: David Freedlander - Momentum vs. Machine The Trump and Harris campaigns battle it out for every last vote.
WIth two weeks left to go, the contours of the 2024 presidential election are clear: Both campaigns need voters who usually don’t vote, and Kamala Harris needs to bring the Democratic coalition, including its Trump-curious members, back home.While the Republican side plans to spend the remaining days of the contest trying to lure low-propensity voters to the polls, the Harris team will attempt to persuade voters of color to return to its side and will try to increase numbers among white voters in previously red suburbs.
Drowning in Slop - A thriving underground economy is clogging the internet with AI garbage-and it's only going to get worse.
SLOP started seeping into Neil Clarke's life in late 2022. Something strange was happening at Clarkesworld, the magazine. Clarke had founded in 2006 and built into a pillar of the world of speculative fiction. Submissions were increasing rapidly, but “there was something off about them,” he told me recently. He summarized a typical example: “Usually, it begins with the phrase ‘In the year 2250-something’ and then it goes on to say the Earth’s environment is in collapse and there are only three scientists who can save us. Then it describes them in great detail, each one with its own paragraph. And then—they’ve solved it! You know, it skips a major plot element, and the final scene is a celebration out of the ending of Star Wars.” Clarke said he had received “dozens of this story in various incarnations.”
The City Politic- The Other Eric Adams Scandal The NYPD shot a fare evader, a cop, and two bystanders. He defends it.
On Sunday, September 15, Derell Mickles hopped a turnstile, got asked to leave by cops, then entered the subway again ten minutes later through an emergency exit. This was at the Sutter Avenue L station, out by his mother's house, five stops from the end of the line. Police said they noticed he was holding a folded knife. They followed him up the stairs to the elevated train, asking him 38 times to drop the weapon.
Can the Media Survive?
BIG TECH, Feckless Owners, CORD-CUTTERS, RESTIVE STAFF, Smaller Audiences ... and the Return of PRINT?
Status Update
Hannah Gadsby's fascinatingly untidy tour through life after fame and death.
A Matter of Perspective
A Matter of Perspective Steve McQueen's worst film is still a solid WWII drama.
Creator, Destroyer
A retrospective reveals an architect's vision, optimism, and supreme arrogance.
In Praise of Bad Readers
In a time of war, there is a danger in surveying the world as if it were a novel.
Trust the Kieran Culkin Process
First, he nearly dropped out of Oscar hopeful A Real Pain. Then he convinced Jesse Eisenberg to change the way he directs.
The Funniest Vampires on TV
What We Do in the Shadows is coming to an end. Its idiosyncratic brand of comedy may be too.
