In July, American pharmaceutical giant Merck completed the $3 billion acquisition of a biotech firm named Eyebio. The deal included a hefty upfront cash payment of $1.3 billion.
The centrepiece of the acquisition was EYE103, a cutting-edge, antibody-based drug with remarkable potential to treat retinal diseases caused by vascular leakage, such as neovascular age-related macular degeneration (NVAMD), diabetic macular oedema (DME), and familial exudative vitreoretinopathy (FEVR).
NVAMD affects over 200 million people globally, while millions more with type-1 or type-2 diabetes are at risk of developing DME. FEVR is a disorder that can lead to progressive vision loss. These conditions had no cures and EYE103 offers hope as a first drug of its kind. Its innovative antibody activates the Wnt-signalling pathway-a protein network that transmits cellular information-strengthening blood vessel integrity in the eye and preventing fluid build-up in the retina.
The antibody molecule in EYE103 is one of thousands of engineered antibodies-each with the potential to become future drugs for a range of serious illnesses, from cancer to rare diseases originating from the lab of Canadian researcher Sachdev Sidhu.
The 55-year-old recently returned to his country of origin for an event. I met him for a teatime interview at a bistro beside the serene artificial lake at the Taj Kumarakom Resort in Kerala. I was expecting a formally attired, jargon-spewing man of science. But, my preconceived notions were quickly shattered. Sidhu, the author of more than 200 scientific papers, a co-inventor on more than 50 patents granted by or filed with the US patent office, and a professor and entrepreneurin-residence at the University of Waterloo, arrived in shorts and a round-neck T-shirt and ordered a glass of wine. In response to one of my early questions, he quoted American rapper Snoop Dogg.
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Denne historien er fra December 01, 2024-utgaven av THE WEEK India.
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Walking in pine forest can have the same effect as a prescription drug
INTERVIEW - KATHY WILLIS, professor of biodiversity, the University of Oxford, and author, Good Nature
MORE THAN A HELPING HAND
Maria Victoria Juan spent a lifetime healing wounded soldiers, and she can't think of anything she could have done better
Against all odds
Mohamed Raishan Ahmed was born with spinal muscular atrophy, which made him unable to sit, stand or walk. Recently, the Maldivian underwent a rare, complex surgery in India that now allows him to sit upright. At 23, the fact that he is alive is in itself an achievement. But he has gone beyond mere survival-with a pursuit of excellence
A pacemaker tale
From science fiction to reality, with a touch of southern Indian wisdom
Driving safe
Taxi drivers endure gruelling hours, cramped seats and relentless traffic, making them prime candidates for health issues like back pain, hypertension, diabetes and insomnia.
Good food, good life
From the moment of birth, we establish a relationship with food—a nourishing link that requires care and attention to stay healthy
POOR SLEEP IN MIDLIFE COULD AGE YOUR BRAIN FASTER
PEOPLE WHO EXPERIENCE SLEEP ISSUES, such as difficulty falling asleep or staying asleep in their 40s, may show more signs of brain ageing in late midlife. Poor sleep may accelerate brain atrophy that is associated with dementia.
BRAIN SCANS SHOW MINDFULNESS MEDITATION CAN REDUCE PAIN
CAN MINDFULNESS MEDITATION actually relieve pain, or is it just a placebo effect?
NON-SURGICAL OPTION TO EASE KNEE ARTHRITIS
A NEW, MINIMALLY INVASIVE procedure called genicular artery embolisation (GAE) can effectively reduce pain, improve quality of life and reduce progression of the disease and the need for knee replacement surgery in people with knee osteoarthritis.
EARLY ONSET DIABETES, BELLY FAT LINKED TO DEMENTIA
FACTORS SUCH AS DIABETES and belly fat in midlife can put you at risk of dementia and Alzheimer's disease later in life.
