Her late Majesty, who died in September aged 96, is said to have had a form of bone marrow cancer.
In her last months, she used a walking cane when out in public.
The speculation comes after the Palace admitted the monarch was suffering "mobility" issues before her death, with symptoms of her suspected cancer including bone pain.
Claims about her secret health woes are made in the upcoming biography of the Queen by friend of the royals Gyles Brandreth.
The monarch's death certificate had officially recorded her cause of death as "old age".
But Gyles says in his Elizabeth: book, An Intimate Portrait: "I heard the Queen had a form of myeloma bone marrow cancer which would explain her tiredness and weight loss and those 'mobility issues"

'Agony' of Queen's final year

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{{magzter}} is the World's largest and fastest growing self-service, cross-platform digital newsstand with over 87 million users since its inception in 2011 and thousands of magazines and newspapers across 40+ categories and 60+ languages. Headquartered in New York, Magzter has its local presence in Amsterdam, London, Mexico City, Chennai, Mumbai, New Delhi, Bengaluru, Singapore, and will soon be expanding to other countries. Founded by global entrepreneurs, Girish Ramdas and Vijay Radhakrishnan in June 2011, Magzter enables magazine and newspaper publishers around the world to create and deliver digital editions of their titles to global consumers.