Somasundaram G, Senior Consultant – Asia Pacific, Global BioPharm Centre of Excellence, Process Solutions, Merck KGaA
Closed processing is considered to be a logical extension of single-use and involves the use of physical barriers to separate processing fluid from the external environment, including the operators. Materials enter or leave the system via predetermined control points.
International Society for Pharmaceutical Engineering (ISPE) defines it as, “A process condition when the product, materials, critical components, or container/closure surfaces are contained and separated from the immediate process environment within closed/sealed process equipment. A process step (or system) in which the product and product contact surfaces are not exposed to the immediate room environment.” In this article, we will define the key drivers for adopting closed processing, what are the pros and cons of closed processing and how some of the innovations are happening in this direction.
Is closed processing the same as connected processing?
Biomanufacturing is steadily moving towards higher efficiency through process intensification. One of the key aspects of intensification is operational excellence through connected processing, resulting in functionally closed bioprocess. The advantages of closed processing are shorter processing time, less manual interactions in the process, reduced CAPEX, reduced resources for cleaning and validation, and reduced need for qualified manufacturing space.
Drive to go for closed processing
Bu hikaye Express Pharma dergisinin June 2021 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber ? Giriş Yap
Bu hikaye Express Pharma dergisinin June 2021 sayısından alınmıştır.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 9,000+ magazines and newspapers.
Already a subscriber? Giriş Yap
Harnessing data analytics to propel drug discovery and development in 2025
As the pharma landscape evolves, data analytics will be at the forefront of drug discovery and development, transforming traditional methods. By leveraging data-driven insights, companies can expedite R&D, optimise clinical trials, and personalise treatments, bringing life-saving therapies to market more efficiently, explains Biju Davis, SVP, Engineering, Model N
Strengthening our presence within APAC through increased penetration is a key focus
Aanchal Tomar, Executive Director, Asia Pacific, Lonza Capsules Health Ingredients speaks about Lonza Capsules Health Ingredients’ strategic growth, challenges, and sustainability initiatives in the APAC market, showcasing their innovative capsule solutions and health ingredients that cater to the region's diverse pharmaceutical and nutraceutical needs, in an interview with Express Pharma
Responsible Sourcing and Manufacturing: Growing towards a sustainable future with Lonza
In response to the establishment of environmental impact targets by the pharmaceutical industry, Lonza promotes responsible sourcing practices, sustainable manufacturing standards, and renewable energy utilisation showcasing that responsible manufacturing can assist our customers to reach their sustainability goals, highlights Christine Lebeault, Head of Applied Sustainability, Lonza Capsules and Health Ingredients
Powerful Process Control with IND500x Weighing Indicators
Ensuring consistent quality in hazardous environments, particularly in Ex-Areas (Zone 1/21, Division 1), is a critical aspect of industrial operations. The IND500x weighing indicators from METTLER TOLEDO provide a robust solution for these challenging settings, offering optimized safety and productivity.
Reshaping pharma safety with active packaging innovations
CILICANT is revolutionising active packaging with solutions tailored for the most sensitive formulations. Meet the innovators driving stability, safety, and impurity control in pharma packaging at CPhI India
Optimising cloud provisioning for pharmaceutical compliance and operational excellence
Suresh Perikala, Senior Engineering Lead - DevOps and Cloud Engineering Practice, Altimetrik
Optimising spend, maximising growth
Express Pharma, in partnership with IPA and CHEMEXCIL, powered by SAP, recently organised a thought leadership conclave on 'Reimagining spend management and supply chain' where cross functional experts explored strategies to drive value through supply chain transformation
Towards a healthier, more equitable and innovative Indian healthcare sector
Rishabh Bindlish, MD & Partner, Co-leads Boston Consulting Group Healthcare practice in India and Ayushi Shukla, Senior Knowledge Analyst, BCG highlight that the government needs to pave the way for a healthier, more equitable future with strategic investments and policy reforms
PROSOLV® SMCC 50-A high-functional excipient from JRS Pharma
The development of coprocessed, multi-functional excipients has enabled formulators to address multiple challenges with a single excipient, resulting in enhanced production and better finished product quality.
Ensuring pharma compliance with testo data measurement technology
Testo data loggers ensure continuous monitoring of temperature and relative humidity of pharma products during production, storage or transit of goods